It activates SIRT1 (sirtuins — the "longevity genes") and the AMPK pathway, mimicking fasting/exercise. An endothelial antioxidant. Only the trans form is biologically active.
Trans vs. Cis — they are not the same thing
Resveratrol exists in two forms (isomers): the trans form is stable and biologically active (found in grape skin); the cis form appears when the trans form is exposed to light/heat — it is practically inactive. Generic supplements may contain a mixture.
Points to watch
- Look for the label: "Trans-Resveratrol standardized ≥98%" — generic products may be cis (inactive).
- Light-sensitive — store it in an amber bottle, in a cool place.
- Oral bioavailability is low; the micronized or phytosome form improves absorption.
- High doses (≥1 g) in longevity studies activate AMPK more robustly.
Mitochondrial synergy
It works very well stacked with PQQ and CoQ10 — while PQQ creates mitochondria and CoQ10 speeds up ATP production, Resveratrol ensures that the cell operates under the "orders" of the sirtuins (cleanup and optimization).
Product in use: LE Optimized Resveratrol Elite
Life Extension's Optimized Resveratrol Elite solves resveratrol's classic problem — extremely low oral bioavailability. Composition (222 mg capsule):
- 40 mg of trans-resveratrol (from Polygonum cuspidatum / Japanese Knotweed, standardized to 18%)
- 77 mg of galactomannans (from fenugreek — they form a coating hydrogel that increases absorption by ~10×)
- 3 mg of Bio-Quercetin® (anti-inflammatory synergy)
How to take
- Dose: 1 capsule in the morning, with a meal containing fat (it enhances polyphenol absorption).
- Bottle: 60 capsules = 60 days.
- Smaller version: 30 caps with 30 mg trans-resveratrol (similar price; lower cost-benefit).